Effects of a Variety of Endotoxins on Human and Rabbit Platelet Function

M Nagayama; M. B Zucker; F. K Beller

doi:10.1055/s-0038-1653699

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1971; 26(03): 467-473
DOI: 10.1055/s-0038-1653699

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Effects of a Variety of Endotoxins on Human and Rabbit Platelet Function

M Nagayama^*

¹Departments of Obstetrics and Gynecology and Pathology, New York University School of Medicine

,

M. B Zucker^**

¹Departments of Obstetrics and Gynecology and Pathology, New York University School of Medicine

,

F. K Beller^***

¹Departments of Obstetrics and Gynecology and Pathology, New York University School of Medicine

› Author Affiliations

Abstract

Summary

Endotoxin from Salmonella typhosa or enteritidis, Escherichia coli, or Serratia marcescens caused platelet aggregation, release of platelet-bound ¹⁴C-serotonin and development of platelet factor 3 activity when shaken at 37 °C with heparinized platelet-rich plasma (10 units/ml) from rabbits. The relative activity in each test differed for each agent. Endotoxoid only released ¹⁴C-serotonin. With human platelet-rich plasma, Salmonella typhosa, E. coli or Serratia marcescens endotoxin failed to induce aggregation or platelet factor 3 activity but caused slow release of platelet-bound ¹⁴C-serotonin. Earlier studies showed that endotoxemia in man or endotoxoid injection in rabbits was associated with thrombocytopenia without shock or disseminated intravascular coagulation. This effect appears to correlate with release of ¹⁴C-serotonin from platelets in vitro.

Full Text

References

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